The Annex sets out test methods for the determination of physicochemical, toxicological and ecotoxicological properties listed in Annexes VII and VIII to Directive 79/831/EEC. The methods are based on those recognized and recommended by competent international bodies (in particular OECD).
When such methods were not available, national standards or scientific consensus methods have been adopted. Generally, tests should be performed with the substance as defined by the Directive. Attention should be given to the possible influence of impurities on the test results.
When the methods of this Annex are inappropriate for the investigation of a certain property, the notifier must justify the alternate method used.
Animal tests and studies shall be conducted in accordance with national regulations and shall take into account humane principles and international developments in the field of animal welfare.
Among equivalent testing methods, the method using the minimum number of animals is chosen.
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